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Autistic Spectrum Disorders (ASD)

    According to DSM-V, released in May 2013, Autistic Spectrum Disorder (ASD) or autism refer to a broad continuum of associated cognitive and neurobehavioral disorders characterized by impairments in social interactions and communications and restricted, repetitive patters of play. ASD affects the normal brain development by altering the normal function of the gastrointestinal, immune, hepatic, endocrine and nervous systems. Children and adults with ASDs usually have particular characteristics in common, however the range and intensity of disability varies. Some individuals are mildly impaired by their symptoms, while others are severely disabled.


    Although the symptoms of autism may begin to present themselves during the first year of child’s life, they tend to be fully evident by the time the child is three years of age. With advances in the field of autism, children with autism are able to be diagnosed as early as 18 months by difficulties orienting to social stimuli, diminished social gaze, language delays and impairments in shared attention and motor imitation. There is evidence that specialized interventions can give people affected by ASD the tools they need to lead full and productive lives.


Causes of Autism

    Autism spectrum disorder is caused by abnormalities in brain structure or function. Brain scans of individuals with ASD have shown differences in the shape and structure of the brain, compared to in neurotypical individuals. Researchers in the field continue to investigate the causes of autism through examination of a number of theories, including the links among heredity, genetics and medical problems.


Family Heritability

    Although there is no known single cause for autism spectrum disorder, recent studies have demonstrated that there is 50- to 100-fold increase in the rate of autism among close blood relatives such as siblings. First-degree relatives of autistic children are found to have higher rates of social difficulties and cognitive deficits, supporting the theory that the disorder has a genetic basis.


Associated Medical or Genetic Conditions

    While no one gene has been identified as causing autism, early reports stated significantly high correlation between fragile X syndrome and autism. More recent molecular genetic studies on this matter, reported either a lower correlation or found no correlation with fragile X syndrome at all. The present evidence indicates that while a few children with autism may have other medical disorders children with other medical disorders often have autistic symptoms.  Other medical disorders in which autism or autistic symptoms appear may include some neurocutaneous disorders, such as tuberous sclerosis, metabolic disorders (e.g., phenylketonuria), intrauterine infections (e.g., rubella, cytomegalovirus) and some genetic disorders (e.g. Williams syndrome).


Behavioural Characteristics of Autism

    While there is marked variability in the severity of the symptoms and level of intellectual functioning in individuals with ASD, they all demonstrate the same core deficits in reciprocal social interactions and verbal, non-verbal language and repetitive/ restricted behaviours. Individuals symptoms and level of functioning may range from severe mental retardation to superior range of intellectual functioning. Since there are currently no biological markers of autism, early screening and diagnosis emphasize on the behaviour of children.The standard criteria for diagnosis are contained within the DSM-V published by the American Psychiatric Association.


Benefits of Early Diagnosis

    Children with autism can often be distinguished from typically developing children as early as 12 months. Despite the presence of the behavioural symptoms early on, many clinicians hesitate to mention the possibility of a diagnosis of autism with parents of very young children due to fear of exacerbating the family’s distress or inadvertently labelling the child with an incorrect diagnosis. The current emphasis on early identification and intervention suggests that the positive outcomes of an early diagnosis, outweigh the negative effects. Early detection is key in helping child’s overall development and living a more normal life in society.




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